Sceletium appears to have inhibitory effects on the serotonin transporter (SERT). It is thought that this is relevant to supplementation of Sceletium as serotonin reuptake inhibitors are used in the treatment of anxiety.
 
Directions:
Adults and children over 12 years of age: Take 1 capsule daily (with or without meals). Dose can be increased to 1 capsule twice daily if needed